Iftach Nachman Lab 

EB during EMT
MEF cells undergoing reprogramming
Foxa2, Brachyury expression in an em
EB Sox2/Oct4 staining
MEFS undergoing reprogramming
GFP,RFP,CFP tagged embryoid body
Brachyury-GFP distribution in an emb

Our goal is to understand how cells within a population reach developmental decisions at the phenotypic and mechanistic level. How do cells “decide” to change their state? Why do similar cells respond differently to the same signal? What properties of the cell internal state affect its decision? How do mechanical and biochemical signals, in the context of a 3D tissue, drive this decision? Our lab studies these fundamental questions in in-vitro 3D mammalian model systems of early development using methods from stem cell biology, live cell fluorescent imaging, microfluidics, statistical and computational analysis.